We generated a novel method for reconstructing neuronal networks of human brain and modeling Alzheimer’s disease in 3D.

We are glad to announce our first ever pre-print server publication that documents an innovative 3D system allowing human neural stem cells to produce our brain’s various neuronal types and to model Alzheimer’s disease with major pathological outcomes replicated outside the brain in a 3D space. With this model, we can study the effects of various molecules on neural stem cells, test the efficiency of drugs on treating Alzheimer’s disease, and address many more interesting and curious questions towards curing Alzheimer’s disease.

The excitement that this work gives us is two-fold. First, it heralds a specific method where we can study Alzheimer’s disease in a controllable and modular experimental reconstruction of our brains in the lab. Second, publishing in Cold Spring Harbor Laboratory‘s archive server BioRxiv is a great experience and will hopefully contribute to the appraisal of fair and for-all open-access publishing policy.



Instructive starPEG-Heparin biohybrid 3D cultures for modeling human neural stem cell plasticity, neurogenesis, and neurodegeneration
Christos Papadimitriou, Mehmet I Cosacak, Violeta Mashkaryan, Hilal Celikkaya, Laura Bray, Prabesh Bhattarai, Heike Hollak, Xin Chen, Shuijin He, Christopher L Antos, Alvin Thomas, Jens Friedrichs, Andreas Dahl, Yixin Zhang, Uwe Freudenberg, Carsten Werner, Caghan Kizil

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