A nice article in The Scientist on the role and promises of adult neurogenesis in Alzheimer's disease. Thanks to Dr. Abby Olena for featuring our previous work in zebrafish and its relationship to decipher how to use adult neurogenesis to tackle Alzheimer's. Reduced Adult Neurogenesis Linked with Alzheimer’s Disease Neural progenitors in a human brain …
Prabesh Bhattarai graduated his PhD
Prabesh Bhattarai successfully defended his PhD thesis and graduated from our lab! Prabesh published 15 papers in respected journals during his PhD with a remarkable record. We wish him all the best for his successful career. Prabesh generated an Alzheimer’s disease model in zebrafish, and identified molecular mechanisms controlling neural stem cell plasticity in experimental …
Mehmet Ilyas Cosacak graduated his PhD
Today is an important and exciting day for our lab. Mehmet Ilyas Cosacak graduated very successfully after defending his PhD thesis that focused on generating neurodegeneration models in zebrafish. He is now a “Dr”. We wholeheartedly congratulate him! His PhD was extraordinary. Ilyas graduated with an outstanding 12 publications. He first authored 5, co-authored 5 …
Collaborative publication in Science Advances
We are glad to be part of this amazing story published today in Science Advances, where functional ramifications of sequential neurogenesis in zebrafish habenula was published by Emre Yaksi Lab in NTNU, Norway. Congrats to all authors! https://advances.sciencemag.org/content/6/36/eaaz3173
Our new review published in Glia
Our open-access review on the comparative aspects of glia in zebrafish and mammals is out at Glia. Big thanks to our institutes and funding agencies for their support. https://doi.org/10.1002/glia.23849
Our single cell sequencing protocol published in STAR Protocols
We are delighted to share our protocol on how to dissect zebrafish telencephalon for single cell sequencing: https://star-protocols.cell.com/protocols/89 This is based on our original research in Cell Reports in 2019 by Cosacak et al. Cosacak, M.I., Bhattarai, P., Reinhardt, S., Petzold, A., Dahl, A., Zhang, Y., and Kizil, C. (2019). Single-cell transcriptomics analyses of neural stem …
Continue reading "Our single cell sequencing protocol published in STAR Protocols"
Kizil Lab tenured in DZNE
Today Kizil Lab is officially tenured at DZNE! We feel humbled upon the trust of DZNE and Helmholtz Association. We'll keep deciphering the mysteries of zebrafish coping with Alzheimer's and thrive to develop novel interventions in the human brain with what zebrafish teaches us. We thank to all former & current lab members as well …
DZNE spotlight on our publication
Our work spotlighted by DZNE: https://www.dzne.de/en/spotlight/meldungen/2020/growing-new-neurons-learning-from-the-fish/
Our new publication: Serotonin orchestrates the neuronal regeneration in Alzheimer’s model of zebrafish brain
We are thrilled to announce our latest paper in PLoS Biology. "Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer’s model of adult zebrafish brain" Our previous research showed that zebrafish is stunning in generating new neurons in response to Alzheimer's disease. But the molecular mechanism underlying was unknown. Here we identified it! By …
World Alzheimer’s Day declaration
Tierversuche Verstehen (an initiative of major research organizations in Germany, such as Max Planck Society, Helmholtz Association, Leibniz Association, DFG, Leopoldina, Fraunhofer Institutes, Alexander von Humboldt Foundation, DAAD, Wissenschaftsrat and others) issued a statement on the future of Alzheimer's disease research. Along with Prof. Chriatian Haass, Prof. Bart De Strooper, Prof. Michael Heneka, Prof. Agnes …
Kizil Lab 