3D – Kizil Lab

November 23, 2022

Our book chapter is published

Our book chapter on 3D hydrogel cultures and modeling Alzheimer's disease is published in Alzheimer's Disease: Methods and Protocols in Methods in Molecular Biology book series. https://link.springer.com/book/10.1007/978-1-0716-2655-9

February 18, 2019February 18, 2019

Novel traumatic injury model of human brain developed in Kizil Lab

Our new publication on how #human #neural #stem cells could increase their ability to regenerate lost #neurons after #traumatic #brain #injury in #3D environment is out! Congratulations to all authors! https://www.frontiersin.org/articles/10.3389/fncel.2019.00023 This work was supported by Deutsches Zentrum für Neurodegenerative Erkrankungen - DZNE TU Dresden IPF Leibniz Institut für Polymerforschung Leibniz-Gemeinschaft Helmholtz-Gemeinschaft Deutscher Forschungszentren Deutsche …

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January 16, 2018January 16, 2018

We generated a novel method for reconstructing neuronal networks of human brain and modeling Alzheimer’s disease in 3D.

We are glad to announce our first ever pre-print server publication that documents an innovative 3D system allowing human neural stem cells to produce our brain's various neuronal types and to model Alzheimer's disease with major pathological outcomes replicated outside the brain in a 3D space. With this model, we can study the effects of …

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About us

The brains of aging humans are prone to neurodegenerative disorders and we are unable to counteract neuronal loss by regenerating lost cells. Patients with neurodegenerative conditions progressively loose neurons yet cannot form new neurons that would replace the lost ones – namely, we humans lack the proper “plasticity response”. We are using zebrafish and novel 3D human culture systems as models to investigate the vertebrate neural stem cells.

Zebrafish regenerates its brain successfully. Our goal is to learn from zebrafish how we can enable the human brain to better cope with neurodegenerative disease and regenerate.

The main motivation of our research group is to understand the molecular programs zebrafish brain uses to induce regenerative stem cell plasticity, and harness this knowledge to unlock the regenerative potential of our brains in Alzheimer’s disease conditions.