A nice article in The Scientist on the role and promises of adult neurogenesis in Alzheimer's disease. Thanks to Dr. Abby Olena for featuring our previous work in zebrafish and its relationship to decipher how to use adult neurogenesis to tackle Alzheimer's. Reduced Adult Neurogenesis Linked with Alzheimer’s Disease Neural progenitors in a human brain …
Collaborative publication in Science Advances
We are glad to be part of this amazing story published today in Science Advances, where functional ramifications of sequential neurogenesis in zebrafish habenula was published by Emre Yaksi Lab in NTNU, Norway. Congrats to all authors! https://advances.sciencemag.org/content/6/36/eaaz3173
Our new review published in Glia
Our open-access review on the comparative aspects of glia in zebrafish and mammals is out at Glia. Big thanks to our institutes and funding agencies for their support. https://doi.org/10.1002/glia.23849
Our single cell sequencing protocol published in STAR Protocols
We are delighted to share our protocol on how to dissect zebrafish telencephalon for single cell sequencing: https://star-protocols.cell.com/protocols/89 This is based on our original research in Cell Reports in 2019 by Cosacak et al. Cosacak, M.I., Bhattarai, P., Reinhardt, S., Petzold, A., Dahl, A., Zhang, Y., and Kizil, C. (2019). Single-cell transcriptomics analyses of neural stem …
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DZNE spotlight on our publication
Our work spotlighted by DZNE: https://www.dzne.de/en/spotlight/meldungen/2020/growing-new-neurons-learning-from-the-fish/
Our new publication: Serotonin orchestrates the neuronal regeneration in Alzheimer’s model of zebrafish brain
We are thrilled to announce our latest paper in PLoS Biology. "Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer’s model of adult zebrafish brain" Our previous research showed that zebrafish is stunning in generating new neurons in response to Alzheimer's disease. But the molecular mechanism underlying was unknown. Here we identified it! By …
World Alzheimer’s Day declaration
Tierversuche Verstehen (an initiative of major research organizations in Germany, such as Max Planck Society, Helmholtz Association, Leibniz Association, DFG, Leopoldina, Fraunhofer Institutes, Alexander von Humboldt Foundation, DAAD, Wissenschaftsrat and others) issued a statement on the future of Alzheimer's disease research. Along with Prof. Chriatian Haass, Prof. Bart De Strooper, Prof. Michael Heneka, Prof. Agnes …
The role of glia in epilepsy – collaborative research published in Nature Communications
It is a pleasure to be involved in the study led by Prof. Dr. Emre Yaksi at the Norwegian University of Science and Technology (NTNU), Norway. The study was published in Nature Communications and discovered that failure of glial cells in the brain triggers the epileptic seizures.
Kizil Lab was in MDR Aktuell news
Our work on Alzheimer's disease and zebrafish was in MDR Aktuell, a national radio broadcaster. Please click on the image above to listen at the broadcaster's website.
We determined the response of all brain cells to Alzheimer’s in single cell resolution
How fish brain cells react to Alzheimer’s disease Zebrafish, in contrast to humans, have outstanding regenerative capacities: If brain cells are lost due to illness or injury, they will easily regrow from so-called progenitor cells. With sophisticated methods, in the German Center for Neurodegenerative Diseases (DZNE) and the Technische Universität Dresden (TUD), we now characterized …
Kizil Lab 