Our work spotlighted by DZNE: https://www.dzne.de/en/spotlight/meldungen/2020/growing-new-neurons-learning-from-the-fish/
Our new publication: Serotonin orchestrates the neuronal regeneration in Alzheimer’s model of zebrafish brain
We are thrilled to announce our latest paper in PLoS Biology. "Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer’s model of adult zebrafish brain" Our previous research showed that zebrafish is stunning in generating new neurons in response to Alzheimer's disease. But the molecular mechanism underlying was unknown. Here we identified it! By …
World Alzheimer’s Day declaration
Tierversuche Verstehen (an initiative of major research organizations in Germany, such as Max Planck Society, Helmholtz Association, Leibniz Association, DFG, Leopoldina, Fraunhofer Institutes, Alexander von Humboldt Foundation, DAAD, Wissenschaftsrat and others) issued a statement on the future of Alzheimer's disease research. Along with Prof. Chriatian Haass, Prof. Bart De Strooper, Prof. Michael Heneka, Prof. Agnes …
The role of glia in epilepsy – collaborative research published in Nature Communications
It is a pleasure to be involved in the study led by Prof. Dr. Emre Yaksi at the Norwegian University of Science and Technology (NTNU), Norway. The study was published in Nature Communications and discovered that failure of glial cells in the brain triggers the epileptic seizures.
Kizil Lab was in MDR Aktuell news
Our work on Alzheimer's disease and zebrafish was in MDR Aktuell, a national radio broadcaster. Please click on the image above to listen at the broadcaster's website.
We determined the response of all brain cells to Alzheimer’s in single cell resolution
How fish brain cells react to Alzheimer’s disease Zebrafish, in contrast to humans, have outstanding regenerative capacities: If brain cells are lost due to illness or injury, they will easily regrow from so-called progenitor cells. With sophisticated methods, in the German Center for Neurodegenerative Diseases (DZNE) and the Technische Universität Dresden (TUD), we now characterized …
Our Alzheimer’s disease model in zebrafish is used for validating a drug that prevents loss of neuronal connections
A collaborative work led by Jared Sterneckert, and in which Kizil Lab was also involved, is now published in the journal Stem Cell Reports, the official journal of International Society for Stem Cell Research (ISSCR). This study identified a lead compound that inhibits CDK5 and GSK3β, and is neuroprotective in vitro and in vivo. Prabesh …
Novel traumatic injury model of human brain developed in Kizil Lab
Our new publication on how #human #neural #stem cells could increase their ability to regenerate lost #neurons after #traumatic #brain #injury in #3D environment is out! Congratulations to all authors! https://www.frontiersin.org/articles/10.3389/fncel.2019.00023 This work was supported by Deutsches Zentrum für Neurodegenerative Erkrankungen - DZNE TU Dresden IPF Leibniz Institut für Polymerforschung Leibniz-Gemeinschaft Helmholtz-Gemeinschaft Deutscher Forschungszentren Deutsche …
Continue reading "Novel traumatic injury model of human brain developed in Kizil Lab"
3D Alzheimer’s disease model and a novel therapy option generated in our lab
Modeling human brain development, inducing Alzheimer's disease, and finding how to cure it in 3D in the lab.
World patent application on our invention for forming a functional network of human neuronal and glial cells
We are happy to announce the publication of our patent as a joint effort of Leibniz Institute of Polymer Research (IPF) and German Center for Neurodegenerative Disease (DZNE). The invention relates to a method for forming a functional network of human neuronal and glial cells, wherein the cells are introduced into a synthetic hydrogel system …
