Our work on Alzheimer's disease and zebrafish was in MDR Aktuell, a national radio broadcaster. Please click on the image above to listen at the broadcaster's website.
We determined the response of all brain cells to Alzheimer’s in single cell resolution
How fish brain cells react to Alzheimer’s disease Zebrafish, in contrast to humans, have outstanding regenerative capacities: If brain cells are lost due to illness or injury, they will easily regrow from so-called progenitor cells. With sophisticated methods, in the German Center for Neurodegenerative Diseases (DZNE) and the Technische Universität Dresden (TUD), we now characterized …
Our Alzheimer’s disease model in zebrafish is used for validating a drug that prevents loss of neuronal connections
A collaborative work led by Jared Sterneckert, and in which Kizil Lab was also involved, is now published in the journal Stem Cell Reports, the official journal of International Society for Stem Cell Research (ISSCR). This study identified a lead compound that inhibits CDK5 and GSK3β, and is neuroprotective in vitro and in vivo. Prabesh …
Novel traumatic injury model of human brain developed in Kizil Lab
Our new publication on how #human #neural #stem cells could increase their ability to regenerate lost #neurons after #traumatic #brain #injury in #3D environment is out! Congratulations to all authors! https://www.frontiersin.org/articles/10.3389/fncel.2019.00023 This work was supported by Deutsches Zentrum für Neurodegenerative Erkrankungen - DZNE TU Dresden IPF Leibniz Institut für Polymerforschung Leibniz-Gemeinschaft Helmholtz-Gemeinschaft Deutscher Forschungszentren Deutsche …
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3D Alzheimer’s disease model and a novel therapy option generated in our lab
Modeling human brain development, inducing Alzheimer's disease, and finding how to cure it in 3D in the lab.
World patent application on our invention for forming a functional network of human neuronal and glial cells
We are happy to announce the publication of our patent as a joint effort of Leibniz Institute of Polymer Research (IPF) and German Center for Neurodegenerative Disease (DZNE). The invention relates to a method for forming a functional network of human neuronal and glial cells, wherein the cells are introduced into a synthetic hydrogel system …
Our new review on pathology-induced regenerative molecular programs of zebrafish brain is out!
We have published a review article on the current knowledge about the damage-induced molecular programs that underlie the regenerative ability in zebrafish brain in Current Pathobiology Reports. The ability to regenerate lost neurons is one of the aims of designing regenerative therapies in humans. Zebrafish, with its extensive regenerative ability and superb aptitude for …
We generated a novel method for reconstructing neuronal networks of human brain and modeling Alzheimer’s disease in 3D.
We are glad to announce our first ever pre-print server publication that documents an innovative 3D system allowing human neural stem cells to produce our brain's various neuronal types and to model Alzheimer's disease with major pathological outcomes replicated outside the brain in a 3D space. With this model, we can study the effects of …
We generated a genetically conditional expression model of TAU protein in adult zebrafish brain
Alzheimer's disease is the most common neurodegenerative disease, and one of the cellular hallmarks is toxicity caused by a protein called TAU. In humans, mutations in TAU leads to disruption of the microtubules, the major transport routes in our neurons. When we lose the integrity of our microtubules, neurons die. A big question is: "Can …
Our video article on generation of Alzheimer’s disease model in adult zebrafish brain is out
Our video article on generation of an Alzheimer's model in zebrafish brain is out in Journal of Visualized Experiments (JoVE). This has been an excellent collaboration with Yixin Zhang Laboratory in B-Cube at TU Dresden and our laboratory in Deutsches Zentrum für Neurodegenerative Erkrankungen - DZNE and CRTD / DFG Center for Regenerative Therapies at …
