Find us at the AD/PD 2023 meeting
We will be presenting two posters and will give a talk on our work in zebrafish, mouse and 3D human cultures in ADPD 2023 meeting in Gothenburg.
We will present our work at Karolinska Institute
Title: "Zebrafish as a new functional genomics tool for Alzheimer’s disease" Zebrafish regenerates its brain successfully even in Alzheimer’s disease conditions. No other animal has been shown to do this. The goal of the Kizil lab is to learn from zebrafish how we can enable the human brain to better cope with neurodegenerative disease and …
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Our book chapter is published
Our book chapter on 3D hydrogel cultures and modeling Alzheimer's disease is published in Alzheimer's Disease: Methods and Protocols in Methods in Molecular Biology book series. https://link.springer.com/book/10.1007/978-1-0716-2655-9
Our collaborative publication on a new epitranscriptomic regulation of Tau pathology published
Using cellular and animal models of Alzheimer's disease as well as human brains from clinical cohorts, Santa-Maria Lab's study identified that the RNA-modifying enzyme NOP2/Sun RNA methyltransferase 2 (NSun2) exerted an epitranscriptomic regulation of miR-125b and tau phosphorylation in Alzheimer's disease. This study highlights a novel avenue for therapeutic targeting. We are glad to have …
Kizil Lab moves to Columbia University!
We are happy to announce that we moved to New York to the Department of Neurology and the Taub Institute in Columbia University Irving Medical Center. We are thrilled to continue and expand on our work in zebrafish on Alzheimer’s disease in the great New York City at this great university! Stay tuned!
Our Viewpoint on the use of zebrafish for Alzheimer’s disease is out in ACS Chemical Neuroscience
We are happy to announce our Viewpoint in ACS Chemical Neuroscience on how zebrafish can help us to understand Alzheimer's disease pathology as well as help design new drugs. Zebrafish as an Experimental and Preclinical Model for Alzheimer’s Disease (click to open the publication at the publisher's site in a separate window) Journal cover from …
We discovered new potent multitarget lead compounds for synaptoprotection in Alzheimer’s disease
Happy to announce our publication in Journal of Medicinal Chemistry: Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer’s Disease (click to open the link on the publisher's site) Graphical abstract Abstract: Drug development efforts that focused on single targets failed to provide effective treatment for Alzheimer’s disease (AD). Therefore, we designed …
Honored to receive the Schaefer Research Scholars Award from Columbia University
Truly honored for the Schaefer Award of the Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons. Thanks to the award committee for this recognition, to our collaborators, mentors and colleagues in Kizil Lab - excellent scientists, without whom the beautiful zebrafish science would not be possible. This goes most to them!
Zebrafish is not far from humans when it comes to how the brain is affected by Alzheimer’s disease
Our recent publication about comprehensive comparison of the single cell/nucleus transcriptomics profiles of human Alzheimer's brains and zebrafish Alzheimer's model is out. We found remarkable similarities and biologically meaningful differences. To compare transcriptomics data in zebrafish model of AD and Alzheimer's patients (in entorhinal cortex, superior frontal gyrus, dorsolateral prefrontal cortex), we first reliably integrated …
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