About us

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Why do we work on Alzheimer’s?

The brains of aging humans are prone to neurodegenerative disorders and we are unable to counteract neuronal loss by regenerating lost cells. Patients with neurodegenerative conditions progressively loose neurons yet cannot form new neurons that would replace the lost ones. We are using zebrafish and novel 3D human culture systems as models to investigate the vertebrate neural stem cells, which we believe are the hope to bring back our lost neurons. We want to find ways how we can restore our brain function in fighting against Alzheimer’s!

What makes our work different?

Zebrafish regenerates its brain successfully even in Alzheimer’s disease conditions. No other animal was shown to do this! Our goal is to learn from zebrafish how we can enable the  human brain to better cope with neurodegenerative disease and regenerate. We have a unique model to work with.

The main motivation of our research group is to understand the molecular programs zebrafish brain uses to induce regenerative stem cell plasticity, and harness this knowledge to unlock the regenerative potential of our brains in Alzheimer’s disease conditions. Check out our publications and presence in the media.

Our lab culture

Our team is composed of young and ambitious scientists. They came from 16 countries in 5 continents, with diverse backgrounds. Kizil Lab derives its success from this richness that cultivates a positive dialogue, gender equality and openness between the team members. With our non-hierarchical approaches to discussions and management, we created a true melting pot where many scientists outside of our lab also aspire to join. Thanks to our lab culture that respects differences and promotes productive team work, our team members bring their extraordinary input and enthusiasm into the new projects. We believe that the team spirit and the congruence generated in Kizil Lab is the reason behind our success.


Our new publication: Serotonin orchestrates the neuronal regeneration in Alzheimer’s model of zebrafish brain

We are thrilled to announce our latest paper in PLoS Biology. “Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer’s model of adult zebrafish brain” Our previous research showed that zebrafish is stunning in generating new neurons in response to Alzheimer’s disease. But the molecular mechanism underlying was unknown. Here we identified it! By …

World Alzheimer’s Day declaration

Tierversuche Verstehen (an initiative of major research organizations in Germany, such as Max Planck Society, Helmholtz Association, Leibniz Association, DFG, Leopoldina, Fraunhofer Institutes, Alexander von Humboldt Foundation, DAAD, Wissenschaftsrat and others) issued a statement on the future of Alzheimer’s disease research. Along with Prof. Chriatian Haass, Prof. Bart De Strooper, Prof. Michael Heneka, Prof. Agnes …