Modeling human brain development, inducing Alzheimer's disease, and finding how to cure it in 3D in the lab.
3D Alzheimer’s disease model and a novel therapy option generated in our lab
World patent application on our invention for forming a functional network of human neuronal and glial cells
We are happy to announce the publication of our patent as a joint effort of Leibniz Institute of Polymer Research (IPF) and German Center for Neurodegenerative Disease (DZNE). The invention relates to a method for forming a functional network of human neuronal and glial cells, wherein the cells are introduced into a synthetic hydrogel system …
Our new review on pathology-induced regenerative molecular programs of zebrafish brain is out!
We have published a review article on the current knowledge about the damage-induced molecular programs that underlie the regenerative ability in zebrafish brain in Current Pathobiology Reports. The ability to regenerate lost neurons is one of the aims of designing regenerative therapies in humans. Zebrafish, with its extensive regenerative ability and superb aptitude for …
We generated a novel method for reconstructing neuronal networks of human brain and modeling Alzheimer’s disease in 3D.
We are glad to announce our first ever pre-print server publication that documents an innovative 3D system allowing human neural stem cells to produce our brain's various neuronal types and to model Alzheimer's disease with major pathological outcomes replicated outside the brain in a 3D space. With this model, we can study the effects of …
We generated a genetically conditional expression model of TAU protein in adult zebrafish brain
Alzheimer's disease is the most common neurodegenerative disease, and one of the cellular hallmarks is toxicity caused by a protein called TAU. In humans, mutations in TAU leads to disruption of the microtubules, the major transport routes in our neurons. When we lose the integrity of our microtubules, neurons die. A big question is: "Can …
Our video article on generation of Alzheimer’s disease model in adult zebrafish brain is out
Our video article on generation of an Alzheimer's model in zebrafish brain is out in Journal of Visualized Experiments (JoVE). This has been an excellent collaboration with Yixin Zhang Laboratory in B-Cube at TU Dresden and our laboratory in Deutsches Zentrum für Neurodegenerative Erkrankungen - DZNE and CRTD / DFG Center for Regenerative Therapies at …
Our publication on the effects of aging on Alzheimer’s model of zebrafish is out
We are happy to announce the publication of our work from our lab at Deutsches Zentrum für Neurodegenerative Erkrankungen - DZNE and CRTD / DFG Center for Regenerative Therapies at the TU Dresden on how aging affects the manifestation of Alzheimer's Disease in zebrafish brain. The report will appear this week in the journal …
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We generated an Amyloid-beta42 toxicity model in adult zebrafish brain
We are happy to announce an advance we achieved in #Alzheimer's research here at our lab. We generated an Amyloid-β42 toxicity model in adult #zebrafish #brain, which shows cell death, microglial activation, synaptic degeneration and learning deficits. Unlike humans, fish brain increase stem cell proliferation and neurogenesis upon Aβ42. We found that Interleukin-4 as a …
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Neural stem cells in Alzheimer’s disease
Alzheimer’s disease is the most prevalent neurodegenerative disease and a worldwide health challenge. Different therapeutic approaches are being developed to revert or slow the loss of affected neurons. Alternatively, we also need to mobilize the existing neural stem/progenitor cells (NSPCs) to regenerate lost neurons despite the existing pathology and unfavorable environment. We need to induce …
Kizil Lab 