Alzheimer’s disease is the most prevalent neurodegenerative disease and a worldwide health challenge. Different therapeutic approaches are being developed to revert or slow the loss of affected neurons. Alternatively, we also need to mobilize the existing neural stem/progenitor cells (NSPCs) to regenerate lost neurons despite the existing pathology and unfavorable environment. We need to induce the “plasticity” of these stem cells. However, there is controversy about how NSPCs are affected by the unfavorable toxic environment during Alzheimer’s disease.
In our recent review published by Yale Journal of Biology and Medicine special issue on “The Aging Brain” (http://www.ncbi.nlm.nih.gov/pmc/issues/266876/), we discussed the use of stem cells in neurodegenerative diseases. In particular, we elaborated on how stem cells affect the Alzheimer’s disease pathology and how neurodegeneration affects stem cells.
In our lab, we are using zebrafish to tackle such questions. If you would like to read our review, please follow the link below: