Neural stem cells in Alzheimer’s disease

Alzheimer’s disease is the most prevalent neurodegenerative disease and a worldwide health challenge. Different therapeutic approaches are being developed to revert or slow the loss of affected neurons. Alternatively, we also need to mobilize the existing neural stem/progenitor cells (NSPCs) to regenerate lost neurons despite the existing pathology and unfavorable environment. We need to induce the “plasticity” of these stem cells. However, there is controversy about how NSPCs are affected by the unfavorable toxic environment during Alzheimer’s disease.