Our Alzheimer’s disease model in zebrafish is used for validating a drug that prevents loss of neuronal connections

Screen Shot 2019-02-21 at 14.14.19

A collaborative work led by Jared Sterneckert, and in which Kizil Lab was also involved, is now published in the journal Stem Cell Reports, the official journal of International Society for Stem Cell Research (ISSCR).

This study identified a lead compound that inhibits CDK5 and GSK3β, and is neuroprotective in vitro and in vivo. Prabesh Bhattarai from Kizil Lab contributed by testing this compound in our adult zebrafish brain Alzheimer‘s model and observed

that LDC8 prevents synaptic degeneration without affecting neuroinflammation.

Congratulations to all authors and we are glad to be part of this exciting work! This study also shows that zebrafish is an excellent tool for finding out and validating chemical compounds that could be used to prevent Alzheimer‘s disease.

Open access full text can be found here: https://doi.org/10.1016/j.stemcr.2019.01.015

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