Zebrafish and Alzheimer's Disease
We are happy to announce the publication of our work from our lab at Deutsches Zentrum für Neurodegenerative Erkrankungen - DZNE and CRTD / DFG Center for Regenerative Therapies at the TU Dresden on how aging affects the manifestation of Alzheimer's Disease in zebrafish brain. The report will appear this week in the journal …
Continue reading "Our publication on the effects of aging on Alzheimer’s model of zebrafish is out"
We are happy to announce an advance we achieved in #Alzheimer's research here at our lab. We generated an Amyloid-β42 toxicity model in adult #zebrafish #brain, which shows cell death, microglial activation, synaptic degeneration and learning deficits. Unlike humans, fish brain increase stem cell proliferation and neurogenesis upon Aβ42. We found that Interleukin-4 as a …
Continue reading "We generated an Amyloid-beta42 toxicity model in adult zebrafish brain"
Alzheimer’s disease is the most prevalent neurodegenerative disease and a worldwide health challenge. Different therapeutic approaches are being developed to revert or slow the loss of affected neurons. Alternatively, we also need to mobilize the existing neural stem/progenitor cells (NSPCs) to regenerate lost neurons despite the existing pathology and unfavorable environment. We need to induce …
