Zebrafish and Alzheimer's Disease
We are excited to share our latest study, published today in Nature Aging, identifying astrocyte-derived fibronectin (FN1) as a key mechanistic driver of blood-brain barrier (BBB) dysfunction in Alzheimer's disease โ and a proximal mediator of the risk conferred by the APOE ฮต4 allele. Building on our earlier work showing that a rare, protective loss-of-function …
We are pleased to share our latest collaborative publication in Alzheimer's & Dementia, a study led by Dr. Christiane Reitz. The work identifies PHLPP1 as a shared genetic locus, providing new insights into the biological mechanisms linking cerebrovascular disease and Alzheimer's disease and highlighting the importance of studying diverse populations in neurogenetics. Ray NR, Kurup …
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We are excited to share a new study, โEvolutionary origins and transcriptomic innovations of vertebrate CajalโRetzius cellsโ, led by Dr. Maria Antonietta Tosches and her lab, now published in Current Biology. This work takes a comparative, cross-species approach to address a long-standing question in neuroscience: are CajalโRetzius (CR) cells a mammalian innovation, or do they …
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We are happy to announce a new preprint from the Kizil Lab, led by first author Elanur Yilmaz, titled โSingleโnucleus multiomics in brains from Hispanic individuals reveal APOEโฮต4โdriven disruption of focal adhesion signaling in the presence of cerebrovascular pathology.โ In this study, our team analyzed 413,175 single nuclei from 52 postmortem brains with high cerebrovascular …
We are excited to share a new preprint from the Kizil Lab titled "APOEโฮต4โinduced Fibronectin at the bloodโbrain barrier is a conserved pathological mediator of disrupted astrocyteโendothelia interaction in Alzheimerโs disease." In this study, we uncover a previously unknown mechanism by which the APOEโฮต4 alleleโone of the strongest genetic risk factors for Alzheimerโs diseaseโdisrupts brain …
We are thrilled to announce our participation in a groundbreaking study in collaboration with Mayo Clinic, now published in Nature Communications. This research looks into the intricate role of blood-brain barrier disruptions in Alzheimerโs disease, leveraging the remarkable capabilities of zebrafish models in combination with vast antemortem and postmortem human brain datasets. The blood-brain barrier …
We discovered a genetic variant that reduces the odds of developing Alzheimerโs disease by up to 70% and may be protecting hundreds of thousands of people from the disease. The discovery of the protective variant, which appears to allow toxic forms of amyloid out of the brain and through theโฏblood-brain barrier, supports emerging evidence that …
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We are glad to announce another preprint from our lab. We have discovered rare genetic variations in a gene associated with the extracellular matrix (ECM) that might protect against Alzheimerโs disease for those at higher genetic risk, specifically individuals carrying the APOEe4 allele. The study used whole genome sequencing data from different cohorts to isolate …
We are glad to share our first bioRxiv preprint in 2024. Alzheimer's disease is characterized by cognitive decline and memory loss, and genetic variations in humans are key to understanding it. Our study focused on the ABCA7 gene, which is linked to Alzheimer's risk. We used CRISPR/Cas9 gene editing to create zebrafish with a genetic …
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A molecular mechanism that zebrafish brain uses to regenerate neurons after neurodegeneration can help us to cope with Alzheimer's, our recent study shows. Induced neurogenesis could be a therapy option for ameliorating Alzheimer's disease pathology. Our recent publication in Nature Partner Journal Regenerative Medicine addresses whether we can use neurogenesis as a means to counteract …
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