Using cellular and animal models of Alzheimer’s disease as well as human brains from clinical cohorts, Santa-Maria Lab’s study identified that the RNA-modifying enzyme NOP2/Sun RNA methyltransferase 2 (NSun2) exerted an epitranscriptomic regulation of miR-125b and tau phosphorylation in Alzheimer’s disease. This study highlights a novel avenue for therapeutic targeting. We are glad to have contributed to this study that is now published in Acta Neuropathologica.
https://link.springer.com/article/10.1007/s00401-022-02511-7
Kizil Lab 