Zebrafish and Alzheimer's Disease
We are glad to share our first bioRxiv preprint in 2024. Alzheimer's disease is characterized by cognitive decline and memory loss, and genetic variations in humans are key to understanding it. Our study focused on the ABCA7 gene, which is linked to Alzheimer's risk. We used CRISPR/Cas9 gene editing to create zebrafish with a genetic …
Continue reading "First preprint research article from Kizil Lab in 2024 out"
We are happy that our Alzheimer’s study in 2023 was selected as one of the best 5 achievements in Neuroscience in 2023 by NeuralCellNews. Thank you! https://twitter.com/NeuralCell/status/1741207280815575518
This year’s Crown Award was presented to Dr. Carol and Gene Ludwig to honor their support of the new research building and establishment of The Carol and Gene Ludwig Center for Research on Neurodegeneration. We are glad to be part of this initiative by participating in one of the seed projects with our zebrafish model.
A molecular mechanism that zebrafish brain uses to regenerate neurons after neurodegeneration can help us to cope with Alzheimer's, our recent study shows. Induced neurogenesis could be a therapy option for ameliorating Alzheimer's disease pathology. Our recent publication in Nature Partner Journal Regenerative Medicine addresses whether we can use neurogenesis as a means to counteract …
Continue reading "More neurons, less Alzheimer’s: from zebrafish to mammals"
We will be presenting two posters and will give a talk on our work in zebrafish, mouse and 3D human cultures in ADPD 2023 meeting in Gothenburg.
Title: "Zebrafish as a new functional genomics tool for Alzheimer’s disease" Zebrafish regenerates its brain successfully even in Alzheimer’s disease conditions. No other animal has been shown to do this. The goal of the Kizil lab is to learn from zebrafish how we can enable the human brain to better cope with neurodegenerative disease and …
Continue reading "We will present our work at Karolinska Institute"
Our book chapter on 3D hydrogel cultures and modeling Alzheimer's disease is published in Alzheimer's Disease: Methods and Protocols in Methods in Molecular Biology book series. https://link.springer.com/book/10.1007/978-1-0716-2655-9
Using cellular and animal models of Alzheimer's disease as well as human brains from clinical cohorts, Santa-Maria Lab's study identified that the RNA-modifying enzyme NOP2/Sun RNA methyltransferase 2 (NSun2) exerted an epitranscriptomic regulation of miR-125b and tau phosphorylation in Alzheimer's disease. This study highlights a novel avenue for therapeutic targeting. We are glad to have …
We are happy to announce that we moved to New York to the Department of Neurology and the Taub Institute in Columbia University Irving Medical Center. We are thrilled to continue and expand on our work in zebrafish on Alzheimer’s disease in the great New York City at this great university! Stay tuned!
Kizil Lab 