Our publication on the effects of aging on Alzheimer’s model of zebrafish is out

  We are happy to announce the publication of our work from our lab at Deutsches Zentrum für Neurodegenerative Erkrankungen - DZNE and CRTD / DFG Center for Regenerative Therapies at the TU Dresden on how aging affects the manifestation of Alzheimer's Disease in zebrafish brain. The report will appear this week in the journal …

We participate in the 1st Dementia Action Day in Dresden

On May 10, 2017, Deutsches Zentrum für Neurodegenerative Erkrankungen - DZNE, CRTD / DFG Center for Regenerative Therapies at the TU Dresden, TU Dresden, Universitätsklinikum Carl Gustav Carus Dresden and Volkshochschule Dresden e.V. are organizing a joint event: Dresden Demetia Day for the first time. Our lab will be giving a public evening lecture organized …

We generated an Amyloid-beta42 toxicity model in adult zebrafish brain

We are happy to announce an advance we achieved in #Alzheimer's research here at our lab. We generated an Amyloid-β42 toxicity model in adult #zebrafish #brain, which shows cell death, microglial activation, synaptic degeneration and learning deficits. Unlike humans, fish brain increase stem cell proliferation and neurogenesis upon Aβ42. We found that Interleukin-4 as a …

Neural stem cells in Alzheimer’s disease

Alzheimer’s disease is the most prevalent neurodegenerative disease and a worldwide health challenge. Different therapeutic approaches are being developed to revert or slow the loss of affected neurons. Alternatively, we also need to mobilize the existing neural stem/progenitor cells (NSPCs) to regenerate lost neurons despite the existing pathology and unfavorable environment. We need to induce …