We generated a novel method for reconstructing neuronal networks of human brain and modeling Alzheimer’s disease in 3D.

We are glad to announce our first ever pre-print server publication that documents an innovative 3D system allowing human neural stem cells to produce our brain's various neuronal types and to model Alzheimer's disease with major pathological outcomes replicated outside the brain in a 3D space. With this model, we can study the effects of …

Two DFG research grants to Kizil Lab!

Our research portfolio is growing with valuable support! We are glad to announce that Deutsche Forschungsgemeinschaft approved two research grants to our laboratory for the next two years! We are proud to be trusted by our colleagues and peer reviewers, and will discover more with this important support!

We generated a genetically conditional expression model of TAU protein in adult zebrafish brain

Alzheimer's disease is the most common neurodegenerative disease, and one of the cellular hallmarks is toxicity caused by a protein called TAU. In humans, mutations in TAU leads to disruption of the microtubules, the major transport routes in our neurons. When we lose the integrity of our microtubules, neurons die. A big question is: "Can …

Our video article on generation of Alzheimer’s disease model in adult zebrafish brain is out

Our video article on generation of an Alzheimer's model in zebrafish brain is out in Journal of Visualized Experiments (JoVE). This has been an excellent collaboration with Yixin Zhang Laboratory in B-Cube at TU Dresden and our laboratory in Deutsches Zentrum für Neurodegenerative Erkrankungen - DZNE and CRTD / DFG Center for Regenerative Therapies at …

Our publication on the effects of aging on Alzheimer’s model of zebrafish is out

  We are happy to announce the publication of our work from our lab at Deutsches Zentrum für Neurodegenerative Erkrankungen - DZNE and CRTD / DFG Center for Regenerative Therapies at the TU Dresden on how aging affects the manifestation of Alzheimer's Disease in zebrafish brain. The report will appear this week in the journal …

We participate in the 1st Dementia Action Day in Dresden

On May 10, 2017, Deutsches Zentrum für Neurodegenerative Erkrankungen - DZNE, CRTD / DFG Center for Regenerative Therapies at the TU Dresden, TU Dresden, Universitätsklinikum Carl Gustav Carus Dresden and Volkshochschule Dresden e.V. are organizing a joint event: Dresden Demetia Day for the first time. Our lab will be giving a public evening lecture organized …

We generated an Amyloid-beta42 toxicity model in adult zebrafish brain

We are happy to announce an advance we achieved in #Alzheimer's research here at our lab. We generated an Amyloid-β42 toxicity model in adult #zebrafish #brain, which shows cell death, microglial activation, synaptic degeneration and learning deficits. Unlike humans, fish brain increase stem cell proliferation and neurogenesis upon Aβ42. We found that Interleukin-4 as a …

Neural stem cells in Alzheimer’s disease

Alzheimer’s disease is the most prevalent neurodegenerative disease and a worldwide health challenge. Different therapeutic approaches are being developed to revert or slow the loss of affected neurons. Alternatively, we also need to mobilize the existing neural stem/progenitor cells (NSPCs) to regenerate lost neurons despite the existing pathology and unfavorable environment. We need to induce …