Zebrafish and Alzheimer's Disease
We’re proud to share our groundbreaking study published in Nature Communications. Our work sheds light on the zebrafish intracardiac nervous system (IcNS)—a local neural network acting as the heart’s "little brain." This was a fantastic collaborative effort between teams at Karolinska Institute and Columbia University, spearheaded by the Konstantinos Ampatzis Lab and Kizil Lab. Huge …
We are proud to announce that our recent publication where we identified a protective genetic variant in FN1 gene against Alzheimer's disease received a recognition award from McAlpine Foundation as one of the best publications in 2024. http://www.mcalpinefoundation.org/awards.php In recognition of the Vardarajan, Kizil, and Mayeux labs' innovative cross-species approach to uncover protective mechanisms against …
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We are excited to share our new study on the role of the ABCA7 gene in brain resilience against Alzheimer’s. Published in Cell Genomics, we found that ABCA7 is crucial for maintaining synaptic health by regulating neuropeptide Y (NPY), a key molecule for brain communication and repair. Loss of ABCA7 reduces NPY, weakening the brain's …
Continue reading "Our study about ABCA7-dependent genetic risk in Alzheimer’s disease is published"
We are glad to announce that we received a Translational Therapeutics Accelerator (TRx) Pilot Award, which provides resources to position therapeutic discoveries for future commercial value. This was a project entitled "Multitarget drugs for therapeutic use in Alzheimer's disease " spearheaded by Dr. Turgutalp at our lab. Congratulations!
We are thrilled to announce our participation in a groundbreaking study in collaboration with Mayo Clinic, now published in Nature Communications. This research looks into the intricate role of blood-brain barrier disruptions in Alzheimer’s disease, leveraging the remarkable capabilities of zebrafish models in combination with vast antemortem and postmortem human brain datasets. The blood-brain barrier …
We discovered a genetic variant that reduces the odds of developing Alzheimer’s disease by up to 70% and may be protecting hundreds of thousands of people from the disease. The discovery of the protective variant, which appears to allow toxic forms of amyloid out of the brain and through the blood-brain barrier, supports emerging evidence that …
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Congratulations to Dr. Prabesh Bhattarai, who is elected as a Toffler Scholar of The Karen Toffler Charitable Trust. "Through partnerships with leading universities, the Toffler Scholar program supports promising young medical researchers, physicians, and scientists who are at a pivotal point in their careers. Where others see risk, we see the potential for profound impact. …
We are glad to announce another preprint from our lab. We have discovered rare genetic variations in a gene associated with the extracellular matrix (ECM) that might protect against Alzheimer’s disease for those at higher genetic risk, specifically individuals carrying the APOEe4 allele. The study used whole genome sequencing data from different cohorts to isolate …
Huge thanks to Columbia University Irving Medical Center for featuring our research along with our fantastic team of zebrafish researchers in CUIMC. https://www.cuimc.columbia.edu/news/fishing-insights-human-disease
On November 13, 2023, benefactors, faculty, and friends from the Columbia University Vagelos College of Physicians and Surgeons (VP&S) community joined together to celebrate the 14th Annual Crown Awards Gala at The Glasshouse in New York City. The evening celebrated how Columbia’s philanthropic partners, faculty, students, and staff are “Transforming Health by Driving Discovery.” We are …
Kizil Lab 