We are happy to announce our Viewpoint in ACS Chemical Neuroscience on how zebrafish can help us to understand Alzheimer's disease pathology as well as help design new drugs. Zebrafish as an Experimental and Preclinical Model for Alzheimer’s Disease (click to open the publication at the publisher's site in a separate window) Journal cover from …
We discovered new potent multitarget lead compounds for synaptoprotection in Alzheimer’s disease
Happy to announce our publication in Journal of Medicinal Chemistry: Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer’s Disease (click to open the link on the publisher's site) Graphical abstract Abstract: Drug development efforts that focused on single targets failed to provide effective treatment for Alzheimer’s disease (AD). Therefore, we designed …
Honored to receive the Schaefer Research Scholars Award from Columbia University
Truly honored for the Schaefer Award of the Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons. Thanks to the award committee for this recognition, to our collaborators, mentors and colleagues in Kizil Lab - excellent scientists, without whom the beautiful zebrafish science would not be possible. This goes most to them!
Zebrafish is not far from humans when it comes to how the brain is affected by Alzheimer’s disease
Our recent publication about comprehensive comparison of the single cell/nucleus transcriptomics profiles of human Alzheimer's brains and zebrafish Alzheimer's model is out. We found remarkable similarities and biologically meaningful differences. To compare transcriptomics data in zebrafish model of AD and Alzheimer's patients (in entorhinal cortex, superior frontal gyrus, dorsolateral prefrontal cortex), we first reliably integrated …
Missing Link Between Alzheimer’s and Vascular Disease Found?
Meeri Kim's article in the Columbia University Irving Medical Center Newsroom on our recent collaborative study with Dr. Annie Lee, Dr. Badri Vardarajan and Dr. Richard Mayeux. For more than 20 years, scientists have known that people with hypertension, diabetes, high cholesterol, or obesity have a higher likelihood of developing Alzheimer’s disease. The conditions can …
Continue reading "Missing Link Between Alzheimer’s and Vascular Disease Found?"
From zebrafish to humans: our work helped to find the missing link between Alzheimer’s and vascular disease
Our study published in Acta Neuropathologica identified an important link between #vascular disease and Alzheimer's in #humans. This publication is a great collaborative effort and included important contribution from zebrafish. FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer’s disease. (Click to be redirected to the publisher's site) …
Admixture Mapping of Alzheimer’s disease in Caribbean Hispanics identifies a new locus on 22q13.1
After years in the making, a beautiful publication about admixture mapping for Alzheimer’s disease in Hispanics is out from Giuseppe Tosto lab at Columbia University. Delighted that zebrafish can contribute to further understanding the human diseases, especially Alzheimer's disease.
DZNE spotlight on our publication
Our work spotlighted by DZNE: https://www.dzne.de/en/spotlight/meldungen/2020/growing-new-neurons-learning-from-the-fish/
Our Alzheimer’s disease model in zebrafish is used for validating a drug that prevents loss of neuronal connections
A collaborative work led by Jared Sterneckert, and in which Kizil Lab was also involved, is now published in the journal Stem Cell Reports, the official journal of International Society for Stem Cell Research (ISSCR). This study identified a lead compound that inhibits CDK5 and GSK3β, and is neuroprotective in vitro and in vivo. Prabesh …
We generated a novel method for reconstructing neuronal networks of human brain and modeling Alzheimer’s disease in 3D.
We are glad to announce our first ever pre-print server publication that documents an innovative 3D system allowing human neural stem cells to produce our brain's various neuronal types and to model Alzheimer's disease with major pathological outcomes replicated outside the brain in a 3D space. With this model, we can study the effects of …
Kizil Lab 