Tag: zebrafish

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Zebrafish is not far from humans when it comes to how the brain is affected by Alzheimer’s disease

Our recent publication about comprehensive comparison of the single cell/nucleus transcriptomics profiles of human Alzheimer's brains and zebrafish Alzheimer's model is out. We found remarkable similarities and biologically meaningful differences. To compare transcriptomics data in zebrafish model of AD and Alzheimer's patients (in entorhinal cortex, superior frontal gyrus, dorsolateral prefrontal cortex), we first reliably integrated …

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Missing Link Between Alzheimer’s and Vascular Disease Found?

Meeri Kim's article in the Columbia University Irving Medical Center Newsroom on our recent collaborative study with Dr. Annie Lee, Dr. Badri Vardarajan and Dr. Richard Mayeux. For more than 20 years, scientists have known that people with hypertension, diabetes, high cholesterol, or obesity have a higher likelihood of developing Alzheimer’s disease. The conditions can …

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From zebrafish to humans: our work helped to find the missing link between Alzheimer’s and vascular disease

Our study published in Acta Neuropathologica identified an important link between #vascular disease and Alzheimer's in #humans. This publication is a great collaborative effort and included important contribution from zebrafish. FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer’s disease. (Click to be redirected to the publisher's site) …

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Our Alzheimer’s disease model in zebrafish is used for validating a drug that prevents loss of neuronal connections

A collaborative work led by Jared Sterneckert, and in which Kizil Lab was also involved, is now published in the journal Stem Cell Reports, the official journal of International Society for Stem Cell Research (ISSCR). This study identified a lead compound that inhibits CDK5 and GSK3β, and is neuroprotective in vitro and in vivo. Prabesh …

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