Tag: astrocyte

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New preprint investigating the pathology mechanisms of Fibronectin at the blood-brain barrier is out

We are excited to share a new preprint from the Kizil Lab titled "APOEโ€‘ฮต4โ€‘induced Fibronectin at the bloodโ€‘brain barrier is a conserved pathological mediator of disrupted astrocyteโ€“endothelia interaction in Alzheimerโ€™s disease." In this study, we uncover a previously unknown mechanism by which the APOEโ€‘ฮต4 alleleโ€”one of the strongest genetic risk factors for Alzheimerโ€™s diseaseโ€”disrupts brain …

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Our study about ABCA7-dependent genetic risk in Alzheimer’s disease is published

We are excited to share our new study on the role of the ABCA7 gene in brain resilience against Alzheimerโ€™s. Published in Cell Genomics, we found that ABCA7 is crucial for maintaining synaptic health by regulating neuropeptide Y (NPY), a key molecule for brain communication and repair. Loss of ABCA7 reduces NPY, weakening the brain's …

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More neurons, less Alzheimer’s: from zebrafish to mammals

A molecular mechanism that zebrafish brain uses to regenerate neurons after neurodegeneration can help us to cope with Alzheimer's, our recent study shows. Induced neurogenesis could be a therapy option for ameliorating Alzheimer's disease pathology. Our recent publication in Nature Partner Journal Regenerative Medicine addresses whether we can use neurogenesis as a means to counteract …

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Zebrafish is not far from humans when it comes to how the brain is affected by Alzheimer’s disease

Our recent publication about comprehensive comparison of the single cell/nucleus transcriptomics profiles of human Alzheimer's brains and zebrafish Alzheimer's model is out. We found remarkable similarities and biologically meaningful differences. To compare transcriptomics data in zebrafish model of AD and Alzheimer's patients (in entorhinal cortex, superior frontal gyrus, dorsolateral prefrontal cortex), we first reliably integrated …

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Missing Link Between Alzheimerโ€™s and Vascular Disease Found?

Meeri Kim's article in the Columbia University Irving Medical Center Newsroom on our recent collaborative study with Dr. Annie Lee, Dr. Badri Vardarajan and Dr. Richard Mayeux. For more than 20 years, scientists have known that people with hypertension, diabetes, high cholesterol, or obesity have a higher likelihood of developing Alzheimerโ€™s disease. The conditions can …

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Novel traumatic injury model of human brain developed in Kizil Lab

Our new publication on how #human #neural #stem cells could increase their ability to regenerate lost #neurons after #traumatic #brain #injury in #3D environment is out! Congratulations to all authors! https://www.frontiersin.org/articles/10.3389/fncel.2019.00023 This work was supported by Deutsches Zentrum fรผr Neurodegenerative Erkrankungen - DZNE TU Dresden IPF Leibniz Institut fรผr Polymerforschung Leibniz-Gemeinschaft Helmholtz-Gemeinschaft Deutscher Forschungszentren Deutsche …

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