Caghan Kizil

 

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Address                                     

Education and Work Experience

  • BSc (Molecular Biology and Genetics), 1999-2003: Molecular Biology and Genetics, Dept. of Molecular Biology and Genetics, Middle East Technical University, Ankara, Turkey.
  • MSc (Molecular Biology), 2003-2005: International Max Planck Research School for Molecular Biology, Göttingen, Germany / Max Planck Institute for Developmental Biology, Dept. of Genetics, Tübingen, Germany (Supervisor: Prof. Dr. Erez Raz).
  • PhD (Developmental Biology), 2005-2009: Max Planck Institute for Developmental Biology, Department of Genetics, Tübingen, Germany (Supervisor: Prof. Dr. Christiane Nüsslein-Volhard).
  • Postdoc (Developmental Genetics, Neuroscience); 2009- 2013: Deutsche Forschungsgemeinschaft (DFG) Cluster of Excellence, Center for Regenerative Therapies Dresden (CRTD), Dresden, Germany. (Mentor: Prof. Dr. Michael Brand)
  • Helmholtz Tenure-Track Young Investigator Group Leader (2014-onwards): German Center for Neurodegenerative Diseases (DZNE) within Helmholtz Association, Dresden, Germany.

Funding, Awards and Fellowships

  • Novo Nordisk Foundation Fellowship / Copenhagen Bioscience Conference (2018)
  • Deutsche Forschungsgemeinschaft Research Grant (2018-2020)
  • Deutsche Forschungsgemeinschaft Research Grant (2017-2019)
  • DZNE Innovation to Application I2A Award (2016-2017)
  • Helmholtz Association Young Investigator Award (2014-2018)
  • Alzheimer Intiative e.V. Research Award (joint) (2014-2016)
  • Deutsche Forschungsgemeinschaft Research Grant (2015-2018)
  • Gordon Meeting Neural Development Travel and Participation Grant (2014)
  • The Company of Biologists, Development Traveling Fellowship (2013)
  • International Society for Stem Cell Research (ISSCR). Travel and Participation Award (2012)
  • National Institutes of Health (NIH). Keystone Meeting Scholarship. (2012)
  • Gordon Research Conferences. Participation and Travel Grant (2011)
  • Technische Universitaet Dresden. Research Stipend. (2010)
  • 6th Framework Project Core Funding / ZF-MODELS (project participation, 2006-2008)
  • Max Planck Society. Stipend for graduate studies. (2005-2009)
  • METU scholarship for basic sciences (1999-2003)
  • Ministry of Education fellowship for undergraduate studies (1999)
  • Türkiye Is Bankasi A.S University Entrance Exams Success Award (1999).
  • Ministry of Education Distinction Award (1999)

Publications

  • Papadimitriou C, Celikkaya H, Cosacak MI, Mashkaryan V, Bray L, Bhattarai P, Brandt K, Hollak H, Chen X, He S, Antos CL, Lin W, Thomas AK, Dahl A, Kurth T, Friedrichs J, Zhang Y, Freudenberg U, Werner C, Kizil C. (2018) 3D Culture Method for Alzheimer’s Disease Modeling Reveals Interleukin-4 Rescues Aβ42-Induced Loss of Human Neural Stem Cell Plasticity. Developmental Cell. 46(1):85-101.e8. doi: 10.1016/j.devcel.2018.06.005.
  • Kizil, C. (2018). Mechanisms of pathology-induced neural stem cell plasticity and neural regeneration in adult zebrafish brainCurrent Pathobiology Reports. 10.1007/s40139-018-0158-x (PDF)
  • Cosacak, MI, Yigit, H, Kizil, C, Akgul, B. (2018) Re-Arrangements in the Cytoplasmic Distribution of Small RNAs Following the Maternal-to-Zygotic Transition in Drosophila Embryos. Genes 9:82. 10.3390/genes9020082. (PDF)
  • Kizil, C. (2018). Turkish Medical Association central council detained for demanding peace. Lancet. PubMed 10.1016/S0140-6736(18)30201-0 (PDF) + Related Editorial (2018). Lancet. (PDF)
  • Cosacak MI, Bhattarai P, Bocova L, Dzewas T, Mashkaryan V, Papadimitriou C, Brandt K, Hollak H, Antos CL, Kizil C. (2017). Human TAUP301L overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brain. Scientific Reports. 7(1), 12959. PubMed 10.1038/s41598-017-13311-5 (PDF)
  • Bhattarai P, Thomas AK, Mashkaryan V, Cosacak MI, Papadimitriou C, Zhang Y, Kizil C. (2017) Modeling Amyloid-beta42 toxicity and neurodegeneration in adult zebrafish brain. JoVE. 128. PubMed 10.3791/56014
  • Bhattarai P, Thomas AK, Zhang Y, Kizil C. (2017). The effects of ageing on Amyloid-b42-induced neurodegeneration and regeneration in adult zebrafish brain. Neurogenesis. 4(1):e1322666. PubMed 10.1080/23262133.2017.1322666 (PDF)
  • Kizil C. (2017) An existential threat. New Scientist. 234(3121):24-25. doi: 1016/S0262-4079(17)30727-3.
  • Bhattarai P, Thomas AK, Cosacak MI, Papadimitriou C, Mashkaryan V, Froc C, Reinhardt S, Kurth T, Dahl A, Zhang Y, Kizil C. (2016) IL4/STAT6 activates neural stem cells in response to Amyloid-b42 aggregation in adult zebrafish brain. Cell Reports, 17(4): 941-948.
  • Tincer, G., Mashkaryan, V., Bhattarai, P., Kizil, C. (2016). Neural stem/progenitor cells in Alzheimer’s disease. The Yale Journal of Biology and Medicine, 89(1), 23–35.
  • Kizil C. (2016) Degrees of freedom. New Scientist. 231(3084):20-21. doi: 1016/S0262-4079(16)31366-5.
  • Kizil C*, Alberts B, Ayata P, Blobel G, Capecchi M, Clark MM, Curl R, Freiwald WA, Hoffmann R, Mucida D, Nestler EJ, Skotheim JM, Trautmann A, zur Hausen H, Altindis E. (2016). Government: Concern grows for Turkey’s academics. Nature. 529(7587):466. doi: 10.1038/529466a. (*Corresponding author)
  • Kizil C*, Kyritsis N, Brand M. (2015) Effects of inflammation on stem cells: together they strive? EMBO Reports. 16(4):416-26. (corresponding author)
  • Cosacak MI, Papadimitriou C, Kizil C. (2014). Regeneration, plasticity and induced molecular programs in adult zebrafish brain. BioMed Research International. 2015:769763.
  • Kizil C, Iltzsche A, Thomas AK, Bhattarai P, Zhang Y, Brand M. (2015) Efficient Cargo Delivery into Adult Brain Tissue Using Short Cell-Penetrating Peptides. PLoS One. 10(4):e0124073.
  • Kizil C, Küchler B, Yan JJ, Ozhan G, Moro E, Argenton F, Brand M, Weidinger G, Antos CL. (2014) Simplet/Fam53b is required for Wnt signal transduction by regulating β-catenin nuclear localization. Development. 141(18):3529-39.
  • Kyritsis N*, Kizil C*, Brand M. (2014) The role of neuroinflammation in central nervous system regeneration. Trends in Cell Biology. 24(2):128-35 (* equal contribution)
  • Kizil C#, Iltzsche A, Kaslin J, Brand M. (2013) Micromanipulation of gene expression in the adult zebrafish brain using cerebroventricular microinjection of morpholino oligonucleotides. JoVE. e50415 (# Corresponding author)
  • Altindis E, Alpar MA, Aksay E, Beckwith J, Bökel C, Curl RF, Darnell RB, Elledge SJ, Erman B, Frahm J, Goff SP, Greengard P, Hoffmann R, Ilhan B, Kaslin J, Lipkin SM, Poulopoulou C, Raz E, Rubin MA, Salturk M, Schrock RR, Trautmann A, Unutmaz D, Weinstein H, Kizil C*. (2013) Turkey must end violent response to protests. Science. 341(6143):236. (*Corresponding author)
  • Kizil C, Kyritsis N, Dudczig S, Kroehne V, Freudenreich F, Kaslin J, Brand M. (2012) Regenerative neurogenesis from neural progenitor cells requires injury-induced expression of Gata3. Developmental Cell. 23(6): 1230-1237.
  • Kyritsis N, Kizil C, Kroehne V, Zocher S, Kaslin J, Freudenreich D, Iltzsche A, Brand M. (2012) Acute inflammation initiates the regenerative response in the adult zebrafish brain. Science. 338(6112): 1353-1356.
  • Kizil C, Dudczig S, Kyritsis N, Machate A, Blaesche J, Kroehne V, Brand M. (2012). The chemokine receptor cxcr5 regulates the regenerative neurogenesis response in the adult zebrafish brain. Neural Development 7:27.
  • Kizil C, Kaslin J, Kroehne V, Brand M. (2012) Adult neurogenesis and brain regeneration in zebrafish. Developmental Neurobiology 72(3):429-461.
  • Kizil C, Brand M (2011) Cerebroventricular Microinjection (CVMI) into Adult Zebrafish Brain Is an Efficient Misexpression Method for Forebrain Ventricular Cells. PLoS ONE 6(11): e27395.
  • Kizil C. (2011) Academic autonomy: more freedom for Turkish science. Nature. 477(7366):538.
  • Kizil C. (2011) Turkish science seeks freedom. Science. 334(6055):452-3.
  • Kizil C, Otto GW, Geisler R, Nüsslein-Volhard C, Antos CL. (2009). Simplet controls cell proliferation and gene transcription during zebrafish caudal fin regeneration. Developmental Biology. 325(2):329-40.

Selected Invited Talks and Seminars

  • World Preclinical Congress 2018. 18-21 June 2018. Boston, MA, USA
  • 2nd Demetia Action Day. 16 May 2017. Dresden, Germany.
  • European Zebrafish Principal Investigator Meeting, 20-23 March 2018. Trento, Italy.
  • 2nd International Conference on Stem Cells. 1 October 2017. Rhodos, Greece.
  • École normale supérieure. 13 September 2017. Paris, France.
  • Karlsruhe Institute of Technology. 5 September 2017. Karlsruhe, Germany
  • 1st Demetia Action Day. 5 May 2017. Dresden, Germany
  • Columbia University Medical Faculty, Taub Seminar. 24 February 2016. New York City, NY, USA
  • Kavli Institute for Systems Neuroscience, September 11, 2015. Trondheim, Norway
  • Abcam meeting. Adult Neurogenesis: Evolution, Regulation and Function, May 6-8, 2015, Dresden, Germany.
  • Yale University. April 2015. New Haven, CT, US.A
  • Seminar Series in CNRS. 20 March 2015. Gif-sur-Yvette, France.
  • Gordon Research Conferences, Neural Development. 10-15 August 2014. Salve Regina University, Newport, RI, USA.
  • Route 28 Summits in Neurobiology. 5-11 September 2014. Frauenchiemsee, Germany.
  • Molecular Neurosiences Workshop. 3-7 September, Bogazici University, Istanbul, Turkey.
  • Brain and Mind Research Institute (BMRI) Weill Cornell Medical College Special Seminar. 29 May 2014. New York, NY, USA.
  • International Meeting of the German Society of Cell Biology. Regensburg, Germany. 19 March 2014.
  • NERF, IMEC, KU Leuven, Belgium. 10 January 2014.
  • SFB 629 research seminar. University of Münster, Germany. 14 February 2013.
  • International Society for Stem Cell Research (ISSCR) 10th Annual Meeting. Yokohama, Japan. 13-16 June 2012.
  • Gordon Research Conference Tissue Repair & Regeneration. New London, NH, USA. 4-10 June 2011.
  • Wnt Meeting 2010. Stockholm, Sweden. 27-30 October 2010.