We are happy to announce our Viewpoint in ACS Chemical Neuroscience on how zebrafish can help us to understand Alzheimer's disease pathology as well as help design new drugs. Zebrafish as an Experimental and Preclinical Model for Alzheimer’s Disease (click to open the publication at the publisher's site in a separate window) Journal cover from …
We discovered new potent multitarget lead compounds for synaptoprotection in Alzheimer’s disease
Happy to announce our publication in Journal of Medicinal Chemistry: Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer’s Disease (click to open the link on the publisher's site) Graphical abstract Abstract: Drug development efforts that focused on single targets failed to provide effective treatment for Alzheimer’s disease (AD). Therefore, we designed …
Zebrafish is not far from humans when it comes to how the brain is affected by Alzheimer’s disease
Our recent publication about comprehensive comparison of the single cell/nucleus transcriptomics profiles of human Alzheimer's brains and zebrafish Alzheimer's model is out. We found remarkable similarities and biologically meaningful differences. To compare transcriptomics data in zebrafish model of AD and Alzheimer's patients (in entorhinal cortex, superior frontal gyrus, dorsolateral prefrontal cortex), we first reliably integrated …
Missing Link Between Alzheimer’s and Vascular Disease Found?
Meeri Kim's article in the Columbia University Irving Medical Center Newsroom on our recent collaborative study with Dr. Annie Lee, Dr. Badri Vardarajan and Dr. Richard Mayeux. For more than 20 years, scientists have known that people with hypertension, diabetes, high cholesterol, or obesity have a higher likelihood of developing Alzheimer’s disease. The conditions can …
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From zebrafish to humans: our work helped to find the missing link between Alzheimer’s and vascular disease
Our study published in Acta Neuropathologica identified an important link between #vascular disease and Alzheimer's in #humans. This publication is a great collaborative effort and included important contribution from zebrafish. FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimer’s disease. (Click to be redirected to the publisher's site) …
Admixture Mapping of Alzheimer’s disease in Caribbean Hispanics identifies a new locus on 22q13.1
After years in the making, a beautiful publication about admixture mapping for Alzheimer’s disease in Hispanics is out from Giuseppe Tosto lab at Columbia University. Delighted that zebrafish can contribute to further understanding the human diseases, especially Alzheimer's disease.
We identified a new signaling pathway that controls pathology-induced neural stem cell plasticity in zebrafish brain
We show a new signaling mechanism through Kynurenic acid and Aryl hydrocarbon receptor in regulating the proliferation of a specific subset of neural stem cells in adult #zebrafish model of #Alzheimer's disease. https://www.mdpi.com/2073-4409/10/10/2748
Locomotion dependent neuron-glia interactions control neurogenesis and regeneration in the adult zebrafish spinal cord
Happy to share our new paper on the non-neuronal / non-motor functions of the spinal locomotor network from Konstantinos Ampatzis Lab. We are glad to be collaborators and contributors to this study published in Nature Communications. https://www.nature.com/articles/s41467-021-25052-1
Our studies featured in The Scientist
A nice article in The Scientist on the role and promises of adult neurogenesis in Alzheimer's disease. Thanks to Dr. Abby Olena for featuring our previous work in zebrafish and its relationship to decipher how to use adult neurogenesis to tackle Alzheimer's. Reduced Adult Neurogenesis Linked with Alzheimer’s Disease Neural progenitors in a human brain …
Collaborative publication in Science Advances
We are glad to be part of this amazing story published today in Science Advances, where functional ramifications of sequential neurogenesis in zebrafish habenula was published by Emre Yaksi Lab in NTNU, Norway. Congrats to all authors! https://advances.sciencemag.org/content/6/36/eaaz3173
Kizil Lab 