Zebrafish and Alzheimer's Disease
We are glad to share our first bioRxiv preprint in 2024. Alzheimer's disease is characterized by cognitive decline and memory loss, and genetic variations in humans are key to understanding it. Our study focused on the ABCA7 gene, which is linked to Alzheimer's risk. We used CRISPR/Cas9 gene editing to create zebrafish with a genetic …
Continue reading "First preprint research article from Kizil Lab in 2024 out"
We are happy that our Alzheimer’s study in 2023 was selected as one of the best 5 achievements in Neuroscience in 2023 by NeuralCellNews. Thank you! https://twitter.com/NeuralCell/status/1741207280815575518
This year’s Crown Award was presented to Dr. Carol and Gene Ludwig to honor their support of the new research building and establishment of The Carol and Gene Ludwig Center for Research on Neurodegeneration. We are glad to be part of this initiative by participating in one of the seed projects with our zebrafish model.
A molecular mechanism that zebrafish brain uses to regenerate neurons after neurodegeneration can help us to cope with Alzheimer's, our recent study shows. Induced neurogenesis could be a therapy option for ameliorating Alzheimer's disease pathology. Our recent publication in Nature Partner Journal Regenerative Medicine addresses whether we can use neurogenesis as a means to counteract …
Continue reading "More neurons, less Alzheimer’s: from zebrafish to mammals"
We are happy to announce that we moved to New York to the Department of Neurology and the Taub Institute in Columbia University Irving Medical Center. We are thrilled to continue and expand on our work in zebrafish on Alzheimer’s disease in the great New York City at this great university! Stay tuned!
We are happy to announce our Viewpoint in ACS Chemical Neuroscience on how zebrafish can help us to understand Alzheimer's disease pathology as well as help design new drugs. Zebrafish as an Experimental and Preclinical Model for Alzheimer’s Disease (click to open the publication at the publisher's site in a separate window) Journal cover from …
Happy to announce our publication in Journal of Medicinal Chemistry: Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer’s Disease (click to open the link on the publisher's site) Graphical abstract Abstract: Drug development efforts that focused on single targets failed to provide effective treatment for Alzheimer’s disease (AD). Therefore, we designed …
Truly honored for the Schaefer Award of the Columbia University Irving Medical Center, Vagelos College of Physicians and Surgeons. Thanks to the award committee for this recognition, to our collaborators, mentors and colleagues in Kizil Lab - excellent scientists, without whom the beautiful zebrafish science would not be possible. This goes most to them!
Our recent publication about comprehensive comparison of the single cell/nucleus transcriptomics profiles of human Alzheimer's brains and zebrafish Alzheimer's model is out. We found remarkable similarities and biologically meaningful differences. To compare transcriptomics data in zebrafish model of AD and Alzheimer's patients (in entorhinal cortex, superior frontal gyrus, dorsolateral prefrontal cortex), we first reliably integrated …
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