Tag: mouse

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New preprint investigating the pathology mechanisms of Fibronectin at the blood-brain barrier is out

We are excited to share a new preprint from the Kizil Lab titled "APOEโ€‘ฮต4โ€‘induced Fibronectin at the bloodโ€‘brain barrier is a conserved pathological mediator of disrupted astrocyteโ€“endothelia interaction in Alzheimerโ€™s disease." In this study, we uncover a previously unknown mechanism by which the APOEโ€‘ฮต4 alleleโ€”one of the strongest genetic risk factors for Alzheimerโ€™s diseaseโ€”disrupts brain …

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More neurons, less Alzheimer’s: from zebrafish to mammals

A molecular mechanism that zebrafish brain uses to regenerate neurons after neurodegeneration can help us to cope with Alzheimer's, our recent study shows. Induced neurogenesis could be a therapy option for ameliorating Alzheimer's disease pathology. Our recent publication in Nature Partner Journal Regenerative Medicine addresses whether we can use neurogenesis as a means to counteract …

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From zebrafish to humans: our work helped to find the missing link between Alzheimer’s and vascular disease

Our study published in Acta Neuropathologica identified an important link between #vascular disease and Alzheimer's in #humans. This publication is a great collaborative effort and included important contribution from zebrafish. FMNL2 regulates gliovascular interactions and is associated with vascular risk factors and cerebrovascular pathology in Alzheimerโ€™s disease. (Click to be redirected to the publisher's site) …

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