Tag: fibronectin

Posted on

New preprint investigating the pathology mechanisms of Fibronectin at the blood-brain barrier is out

We are excited to share a new preprint from the Kizil Lab titled "APOE‑ε4‑induced Fibronectin at the blood‑brain barrier is a conserved pathological mediator of disrupted astrocyte–endothelia interaction in Alzheimer’s disease." In this study, we uncover a previously unknown mechanism by which the APOE‑ε4 allele—one of the strongest genetic risk factors for Alzheimer’s disease—disrupts brain …

Continue reading "New preprint investigating the pathology mechanisms of Fibronectin at the blood-brain barrier is out"

Posted on

We found a genetic variant that protects against Alzheimer’s disease

We discovered a genetic variant that reduces the odds of developing Alzheimer’s disease by up to 70% and may be protecting hundreds of thousands of people from the disease. The discovery of the protective variant, which appears to allow toxic forms of amyloid out of the brain and through the blood-brain barrier, supports emerging evidence that …

Continue reading "We found a genetic variant that protects against Alzheimer’s disease"