Tag: APOE

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Our preprint about new insights from human brains into APOE‑ε4 in vascular pathology and Alzheimer’s disease risk is out

We are happy to announce a new preprint from the Kizil Lab, led by first author Elanur Yilmaz, titled “Single‑nucleus multiomics in brains from Hispanic individuals reveal APOE‑ε4‑driven disruption of focal adhesion signaling in the presence of cerebrovascular pathology.” In this study, our team analyzed 413,175 single nuclei from 52 postmortem brains with high cerebrovascular …

Continue reading "Our preprint about new insights from human brains into APOE‑ε4 in vascular pathology and Alzheimer’s disease risk is out"

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New preprint investigating the pathology mechanisms of Fibronectin at the blood-brain barrier is out

We are excited to share a new preprint from the Kizil Lab titled "APOE‑ε4‑induced Fibronectin at the blood‑brain barrier is a conserved pathological mediator of disrupted astrocyte–endothelia interaction in Alzheimer’s disease." In this study, we uncover a previously unknown mechanism by which the APOE‑ε4 allele—one of the strongest genetic risk factors for Alzheimer’s disease—disrupts brain …

Continue reading "New preprint investigating the pathology mechanisms of Fibronectin at the blood-brain barrier is out"